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Xerese Review

If applied early at the first signs of a cold sore, XERESE is believed to lessen the chance of the sore ulcerating and later on also works to shorten the time it takes to heal the symptoms when cold sores have developed.


Xerese is made with 5% acyclovir and 1% hydrocortisone. It is available in 2-gram and 5-gram tubes.


XERESE cream is used to combat herpes labialis, the condition behind cold sores- in the early phases. Its use is supposed to lessen the chances of developing cold sores and reduce the time it takes to heal the symptoms of cold sores in people above 12. Therapy should be initiated as early as possible after the first signs and symptoms.
XERESE Cream is supposed to be administered for cutaneous use only, specifically on the lips and around the mouth. It should not be used in the eye, inside the mouth or nose, or on the genitals.

The effect of XERESE Cream has not been proven beyond doubt in immune-compromised patients due to an absence of reliable information. Similarly, in pediatric cases, its safety and effectiveness in subjects under 12 has not been demonstrated beyond doubt.


Xerese is applied by spreading a thin layer on the affected area. XERESE should be applied 5 times per day for 5 days. It is recommended that one should begin using XERESE as early as possible in the event of the first tell-tale symptoms of a cold sore appearing.


Each gram of XERESE (cream made up of hydrocortisone and acyclovir) is made with 5% (w/w) of acyclovir, 1% (w/w) hydrocortisone. The Xerese cream has an aqueous base. Resource sites list the inactive compounds in the cream: citric acid, cetostearyl alcohol, water, mineral oil, sodium hydroxide, Poloxamer 188, white petrolatum, propylene glycol, sodium lauryl sulfate and isopropyl myristate.

Side Effects

Some people treated with Xerese in clinical trials were said to have developed a number of side effects. Some complained of dry, itchy or flaky skin after using the cream. There were reports of the cream stinging or leaving a burn-like feeling on the skin. Further side effects reported were bitterness in the mouth, swollen skin, erythema. Some of the allergic responses included hives, itches, rashes, breathing problems, chest discomfort, facial or oral swell-ups, changes in skin color where applied, etc. Apparently, these were reported in fewer than 1% of the trial cases.


XERESE is prepared under the supervision of Meda Pharma SARL, which is a company affiliated to Valeant Pharmaceuticals International Inc. Their primary base is in Montreal in Canada.

Where To Get It?

Xerese needs a prescription although it is also sold online. Some online pharmacies may attempt to sell a generic version of Xerese which is illegal. These are counterfeit medications that may potentially be unsafe.


A selection of Prices for one 5g tube of 5%/1% Xerese cream as listed here;

Sams Club - $319.88

Kroger Pharmacy $ 325.79
Kmart - $ 326.47
Publix - $ 326.74
CVS Pharmacy - $ 329.97
Walgreens - $ 330.22
Rite-Aid $ 330.22
Target - $ 330.97
Walmart - $ 338.62 coupon not necessary

XERESE is a medicine used to relieve the discomfort caused by cold sores. It is mostly prescribed for patients above 12. Xerese is known to have the ingredient acyclovir, a substance that is meant to work well in towards easing the symptoms associated with the persistent herpes viruses. It also has hydrocortisone, which is a corticosteroid known to have anti-inflammatory powers. It is a medicated cream that can be used easily. Xerese is thought to be the pioneering treatment in the use of both anti-inflammatory and antiviral elements to target cold sores.


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Xerese Review